Event

Nambour skin cancer prevention trial

Randomised trial that began in 1992 in Nambour, Queensland: daily sunscreen against use as people chose, and beta-carotene against placebo.

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Connections 4

Sunscreen daily SPF 15-plus use against use as people chose Scholarship & press 1

Timeline 1 date

Proof 2 sources

Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial (abstract), The Lancet, 28 Aug 1999. Scholarship & press
daily application of a sun protection factor 15-plus sunscreen to the head, neck, arms, and hands
Participants were 1621 residents of Nambour in southeast Queensland, Australia.
There were no significant differences in the incidence of first new skin cancers between groups randomly assigned daily sunscreen and no daily sunscreen
There was no harmful effect of daily use of sunscreen in this medium-term study.
Reduced melanoma after regular sunscreen use: randomized trial follow-up (abstract), Journal of Clinical Oncology, 20 Jan 2011. Scholarship & press
Participants were observed until 2006 with questionnaires and/or through pathology laboratories and the cancer registry to ascertain primary melanoma occurrence.
The reduction in invasive melanomas was substantial (n = 3 in active v 11 in control group; HR, 0.27; 95% CI, 0.08 to 0.97) compared with that for preinvasive melanomas (HR, 0.73; 95% CI, 0.29 to 1.81).
Melanoma may be preventable by regular sunscreen use in adults.
In 1992, 1,621 randomly selected residents of Nambour, a township in Queensland, Australia, age 25 to 75 years, were randomly assigned to daily or discretionary sunscreen application to head and arms in combination with 30 mg beta carotene or placebo supplements until 1996.

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