Artifact

Tretinoin

A form of vitamin A used on the skin; the first retinoid the FDA approved for acne, in 1971.

3 links, 1 backed by primary records

Connections 3

Weiss et al., JAMA, 1988: topical tretinoin and photoaged skin the treatment tested Scholarship & press 1
Tretinoin cream prescription label a prescription drug with a sun-exposure caution Primary record 2
40 Years of Topical Tretinoin Use in Review (2013) the treatment reviewed Scholarship & press 3

Proof 3 sources

Topical tretinoin improves photoaged skin: a double-blind vehicle-controlled study (abstract), JAMA, 22 Jan 1988. Scholarship & press
In a 16-week randomized, double-blind, vehicle-controlled study of topical tretinoin in the treatment of photoaging
Fourteen of the 15 patients who received tretinoin to the face had improvement in photoaging, whereas none of the vehicle-treated patients' faces improved
Side effects were limited to irritation of tretinoin-exposed skin.
Tretinoin cream label (DailyMed, U.S. National Library of Medicine), U.S. National Library of Medicine, 13 Feb 2025. Primary record
Tretinoin Cream 0.1% NDC 62032-417-20 Rx only
Exposure to sunlight, including sunlamps, should be minimized during the use of tretinoin
40 Years of Topical Tretinoin Use in Review, Journal of Drugs in Dermatology, 1 Jun 2013. Scholarship & press
In 1971, tretinoin became the first retinoid to be approved by the US Food and Drug Administration (FDA) as a topical treatment for acne vulgaris (AV).
In 1995, topical tretinoin was approved by the FDA for the palliation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial photodamage.

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